Chair for Drug Formulation and Delivery

    Poorly Water Soluble Drugs

    Formulation of Poorly Water Soluble Drugs (PWSDs)

    • Experimental determination of pKa, logP and kinetics of precipitations and dissolution of the pure PWSD and in the presence of additives
    • Systematic development of supersaturating systems for the improvement of the biopharmaceutical properties, including a ‘high throughput’ platform for fast identification of suitable formulations
    • Transformation of PWSDs into ionic liquids by tailor-made counterions as well as themodynamic, pharmaceutical, chemical, and biopharmaceutical characterization
    • Development of powder diffraction as a platform for the online-monitoring of precipitation and crystallinity of PWSDs in biologically relevant fluids

    Therapeutic Gas Delivery

    • Development of oral delivery systems for therapeutic gases such as CO, H2S, or NO

    Publication Highlights

    Balk, A., Widmer, T., Wiest, J., et al. (2015) "Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges" Pharm. Research [Epub ahead of print],  http://www.ncbi.nlm.nih.gov/pubmed/25534684

    Steiger, C., Lühmann, T., et al. (2014). "Oral drug delivery of therapeutic gases -carbon monoxide release for gastrointestinal diseases." J Control Release 189: 46-53. http://www.ncbi.nlm.nih.gov/pubmed/24969354