Publications

Investigations Into Chemically Stabilized Four-Letter DNA for DNA-Encoded Chemistry Potowski, Marco; Kunig, Verena B. K.; Eberlein, Lukas; Škopić, Mateja Klika; Vakalopoulos, Alexandros; Kast, Stefan M.; Brunschweiger, Andreas in Frontiers in Chemistry (2022). 10

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%0 Journal Article
%1 10.3389/fchem.2022.894563
%A Potowski, Marco
%A Kunig, Verena B. K.
%A Eberlein, Lukas
%A Škopić, Mateja Klika
%A Vakalopoulos, Alexandros
%A Kast, Stefan M.
%A Brunschweiger, Andreas
%D 2022
%J Frontiers in Chemistry
%R 10.3389/fchem.2022.894563
%T Investigations Into Chemically Stabilized Four-Letter DNA for DNA-Encoded Chemistry
%U https://www.frontiersin.org/articles/10.3389/fchem.2022.894563
%V 10
%X DNA-encoded libraries are a prime technology for target-based small molecule screening. Native DNA used as genetic compound barcode is chemically vulnerable under many reaction conditions. DNA barcodes that are composed of pyrimidine nucleobases, 7-deazaadenine, and 7-deaza-8-azaguanine have been investigated for their suitability for encoded chemistry both experimentally and computationally. These four-letter barcodes were readily ligated by T4 ligation, amplifiable by Taq polymerase, and the resultant amplicons were correctly sequenced. Chemical stability profiling showed a superior chemical stability compared to native DNA, though higher susceptibility to depurination than a three-letter code based on pyrimidine DNA and 7-deazaadenine.

Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp3-Rich Heterocycles by SnAP Chemistry Škopi’c, Mateja Klika; Losch, Florian; McMillan, Angus E.; Willeke, Niklas; Malenica, Mateo; Bering, Luis; Bode, Jeffrey; Brunschweiger, Andreas in Organic Letters (2022). 24(6) 1383–1387.

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%0 Journal Article
%1 _kopi__2022
%A Škopi'c, Mateja Klika
%A Losch, Florian
%A McMillan, Angus E.
%A Willeke, Niklas
%A Malenica, Mateo
%A Bering, Luis
%A Bode, Jeffrey
%A Brunschweiger, Andreas
%D 2022
%I American Chemical Society (ACS)
%J Organic Letters
%N 6
%P 1383--1387
%R 10.1021/acs.orglett.2c00228
%T Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp3-Rich Heterocycles by SnAP Chemistry
%U https://doi.org/10.1021%2Facs.orglett.2c00228
%V 24

Navigating chemical reaction space – application to DNA-encoded chemistry Chines, Silvia; Ehrt, Christiane; Potowski, Marco; Biesenkamp, Felix; Grützbach, Lars; Brunner, Susanne; van den Broek, Frederik; Bali, Shilpa; Ickstadt, Katja; Brunschweiger, Andreas in Chem. Sci. (2022). 13(37) 11221–11231.

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%0 Journal Article
%1 D2SC02474H
%A Chines, Silvia
%A Ehrt, Christiane
%A Potowski, Marco
%A Biesenkamp, Felix
%A Grützbach, Lars
%A Brunner, Susanne
%A van den Broek, Frederik
%A Bali, Shilpa
%A Ickstadt, Katja
%A Brunschweiger, Andreas
%D 2022
%I The Royal Society of Chemistry
%J Chem. Sci.
%N 37
%P 11221-11231
%R 10.1039/D2SC02474H
%T Navigating chemical reaction space – application to DNA-encoded chemistry
%U http://dx.doi.org/10.1039/D2SC02474H
%V 13
%X Databases contain millions of reactions for compound synthesis, rendering selection of reactions for forward synthetic design of small molecule screening libraries, such as DNA-encoded libraries (DELs), a big data challenge. To support reaction space navigation, we developed the computational workflow Reaction Navigator. Reaction files from a large chemistry database were processed using the open-source KNIME Analytics Platform. Initial processing steps included a customizable filtering cascade that removed reactions with a high probability to be incompatible with DEL, as they would e.g. damage the genetic barcode, to arrive at a comprehensive list of transformations for DEL design with applicability potential. These reactions were displayed and clustered by user-defined molecular reaction descriptors which are independent of reaction core substitution patterns. Thanks to clustering, these can be searched manually to identify reactions for DEL synthesis according to desired reaction criteria, such as ring formation or sp3 content. The workflow was initially applied for mapping chemical reaction space for aromatic aldehydes as an exemplary functional group often used in DEL synthesis. Exemplary reactions have been successfully translated to DNA-tagged substrates and can be applied to library synthesis. The versatility of the Reaction Navigator was then shown by mapping reaction space for different reaction conditions, for amines as a second set of starting materials, and for data from a second database.

Functional Group Tolerance of a Micellar on-DNA SuzukitextendashMiyaura Cross-Coupling Reaction for DNA-Encoded Library Design Hunter, James H.; Potowski, Marco; Stanway-Gordon, Harriet A.; Madin, Andrew; Pairaudeau, Garry; Brunschweiger, Andreas; Waring, Michael J. in The Journal of Organic Chemistry (2021). 86(24) 17930–17935.

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%0 Journal Article
%1 Hunter_2021
%A Hunter, James H.
%A Potowski, Marco
%A Stanway-Gordon, Harriet A.
%A Madin, Andrew
%A Pairaudeau, Garry
%A Brunschweiger, Andreas
%A Waring, Michael J.
%D 2021
%I American Chemical Society (ACS)
%J The Journal of Organic Chemistry
%N 24
%P 17930--17935
%R 10.1021/acs.joc.1c02259
%T Functional Group Tolerance of a Micellar on-DNA SuzukitextendashMiyaura Cross-Coupling Reaction for DNA-Encoded Library Design
%U https://doi.org/10.1021%2Facs.joc.1c02259
%V 86

Copper(I/II)-Promoted Diverse Imidazo[1,2-$$\upalpha$$]pyridine Synthesis on Solid-Phase Bound DNA Oligonucleotides for Encoded Library Design Potowski, Marco; Lüttig, Ricarda; Vakalopoulos, Alexandros; Brunschweiger, Andreas in Organic Letters (2021). 23(14) 5480–5484.

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%0 Journal Article
%1 Potowski_2021
%A Potowski, Marco
%A Lüttig, Ricarda
%A Vakalopoulos, Alexandros
%A Brunschweiger, Andreas
%D 2021
%I American Chemical Society (ACS)
%J Organic Letters
%N 14
%P 5480--5484
%R 10.1021/acs.orglett.1c01834
%T Copper(I/II)-Promoted Diverse Imidazo[1,2-\($\upalpha$\)]pyridine Synthesis on Solid-Phase Bound DNA Oligonucleotides for Encoded Library Design
%U https://doi.org/10.1021%2Facs.orglett.1c01834
%V 23

Towards DNA-Encoded Micellar Chemistry: DNA-Micelle Association and Environment Sensitivity of Catalysis Škopi’c, Mateja Klika; Gramse, Christian; Oliva, Rosario; Pospich, Sabrina; Neukirch, Laura; Manisegaran, Magiliny; Raunser, Stefan; Winter, Roland; Weberskirch, Ralf; Brunschweiger, Andreas in Chemistry textendash A European Journal (2021). 27(39) 10048–10057.

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%0 Journal Article
%1 Klika_kopi__2021
%A Škopi'c, Mateja Klika
%A Gramse, Christian
%A Oliva, Rosario
%A Pospich, Sabrina
%A Neukirch, Laura
%A Manisegaran, Magiliny
%A Raunser, Stefan
%A Winter, Roland
%A Weberskirch, Ralf
%A Brunschweiger, Andreas
%D 2021
%I Wiley
%J Chemistry textendash A European Journal
%N 39
%P 10048--10057
%R 10.1002/chem.202100980
%T Towards DNA-Encoded Micellar Chemistry: DNA-Micelle Association and Environment Sensitivity of Catalysis
%U https://doi.org/10.1002%2Fchem.202100980
%V 27

TEADtextendashYAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics Kunig, Verena B. K.; Potowski, Marco; Akbarzadeh, Mohammad; Škopi’c, Mateja Klika; Smith, Denise Santos; Arendt, Lukas; Dormuth, Ina; Adihou, Hélène; Andlovic, Blavz; Karatas, Hacer; Shaabani, Shabnam; Zarganes-Tzitzikas, Tryfon; Neochoritis, Constantinos G.; Zhang, Ran; Groves, Matthew; Guéret, Stéphanie M.; Ottmann, Christian; Rahnenführer, Jörg; Fried, Roland; Dömling, Alexander; Brunschweiger, Andreas in Angewandte Chemie International Edition (2020). 59(46) 20338–20342.

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%0 Journal Article
%1 Kunig_2020
%A Kunig, Verena B. K.
%A Potowski, Marco
%A Akbarzadeh, Mohammad
%A Škopi'c, Mateja Klika
%A Smith, Denise Santos
%A Arendt, Lukas
%A Dormuth, Ina
%A Adihou, Hélène
%A Andlovic, Blavz
%A Karatas, Hacer
%A Shaabani, Shabnam
%A Zarganes-Tzitzikas, Tryfon
%A Neochoritis, Constantinos G.
%A Zhang, Ran
%A Groves, Matthew
%A Guéret, Stéphanie M.
%A Ottmann, Christian
%A Rahnenführer, Jörg
%A Fried, Roland
%A Dömling, Alexander
%A Brunschweiger, Andreas
%D 2020
%I Wiley
%J Angewandte Chemie International Edition
%N 46
%P 20338--20342
%R 10.1002/anie.202006280
%T TEADtextendashYAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics
%U https://doi.org/10.1002%2Fanie.202006280
%V 59

Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions Potowski, Marco; Losch, Florian; Wünnemann, Elena; Dahmen, Janina K.; Chines, Silvia; Brunschweiger, Andreas in Chem. Sci. (2019). 10(45) 10481–10492.

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%0 Journal Article
%1 C9SC04708E
%A Potowski, Marco
%A Losch, Florian
%A Wünnemann, Elena
%A Dahmen, Janina K.
%A Chines, Silvia
%A Brunschweiger, Andreas
%D 2019
%I The Royal Society of Chemistry
%J Chem. Sci.
%N 45
%P 10481-10492
%R 10.1039/C9SC04708E
%T Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions
%U http://dx.doi.org/10.1039/C9SC04708E
%V 10
%X DNA-encoded compound libraries are a widely used technology for target-based small molecule screening. Generally, these libraries are synthesized by solution phase combinatorial chemistry requiring aqueous solvent mixtures and reactions that are orthogonal to DNA reactivity. Initiating library synthesis with readily available controlled pore glass-coupled DNA barcodes benefits from enhanced DNA stability due to nucleobase protection and choice of dry organic solvents for encoded compound synthesis. We screened the compatibility of solid-phase coupled DNA sequences with 53 metal salts and organic reagents. This screening experiment suggests design of encoded library synthesis. Here, we show the reaction optimization and scope of three sp3-bond containing heterocyclic scaffolds synthesized on controlled pore glass-connected DNA sequences. A ZnCl2-promoted aza-Diels–Alder reaction with Danishefsky's diene furnished diverse substituted DNA-tagged pyridones, and a phosphoric acid organocatalyst allowed for synthesis of tetrahydroquinolines by the Povarov reaction and pyrimidinones by the Biginelli reaction, respectively. These three reactions caused low levels of DNA depurination and cover broad and only partially overlapping chemical space though using one set of DNA-coupled starting materials.

Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry Potowski, Marco; Kunig, Verena B. K.; Losch, Florian; Brunschweiger, Andreas in Med. Chem. Commun. (2019). 10(7) 1082–1093.

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%0 Journal Article
%1 C9MD00042A
%A Potowski, Marco
%A Kunig, Verena B. K.
%A Losch, Florian
%A Brunschweiger, Andreas
%D 2019
%I The Royal Society of Chemistry
%J Med. Chem. Commun.
%N 7
%P 1082-1093
%R 10.1039/C9MD00042A
%T Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry
%U http://dx.doi.org/10.1039/C9MD00042A
%V 10
%X DNA-encoded libraries of chemically synthesized compounds are an important small molecule screening technology. The synthesis of encoded compounds in solution is currently restricted to a few DNA-compatible and water-tolerant reactions. Encoded compound synthesis of short DNA-barcodes covalently connected to solid supports benefits from a broad range of choices of organic solvents. Here, we show that this encoded chemistry approach allows for the synthesis of DNA-coupled isoquinolones by an Yb(iii)-mediated Castagnoli–Cushman reaction under anhydrous reaction conditions and for the synthesis of highly substituted pyrrolidines by Ag(i)-mediated 1,3-dipolar azomethine ylide cycloaddition. An encoding scheme for these DNA-barcoded compounds based on a DNA hairpin is demonstrated.

Micellar Bronsted Acid Mediated Synthesis of DNA-Tagged Heterocycles Škopi’c, M. Klika; Götte, K.; Gramse, C.; Dieter, M.; Pospich, S.; Raunser, S.; Weberskirch, R.; Brunschweiger, A. in Journal of the American Chemical Society (2019). 141(26) 10546–10555.

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%0 Journal Article
%1 _kopi__2019
%A Škopi'c, M. Klika
%A Götte, K.
%A Gramse, C.
%A Dieter, M.
%A Pospich, S.
%A Raunser, S.
%A Weberskirch, R.
%A Brunschweiger, A.
%D 2019
%I American Chemical Society (ACS)
%J Journal of the American Chemical Society
%N 26
%P 10546--10555
%R 10.1021/jacs.9b05696
%T Micellar Bronsted Acid Mediated Synthesis of DNA-Tagged Heterocycles
%U https://doi.org/10.1021%2Fjacs.9b05696
%V 141

DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences Kunig, Verena; Potowski, Marco; Gohla, Anne; Brunschweiger, Andreas in Biological Chemistry (2018). 399(7) 691–710.

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%0 Journal Article
%1 KunigPotowskiGohlaBrunschweiger+2018+691+710
%A Kunig, Verena
%A Potowski, Marco
%A Gohla, Anne
%A Brunschweiger, Andreas
%D 2018
%J Biological Chemistry
%N 7
%P 691--710
%R doi:10.1515/hsz-2018-0119
%T DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences
%U https://doi.org/10.1515/hsz-2018-0119
%V 399

Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold Škopić, M. Klika; Bugain, O.; Jung, K.; Onstein, S.; Brandherm, S.; Kalliokoski, T.; Brunschweiger, A. in Med. Chem. Commun. (2016). 7(10) 1957–1965.

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%0 Journal Article
%1 C6MD00243A
%A Škopić, M. Klika
%A Bugain, O.
%A Jung, K.
%A Onstein, S.
%A Brandherm, S.
%A Kalliokoski, T.
%A Brunschweiger, A.
%D 2016
%I The Royal Society of Chemistry
%J Med. Chem. Commun.
%N 10
%P 1957-1965
%R 10.1039/C6MD00243A
%T Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold
%U http://dx.doi.org/10.1039/C6MD00243A
%V 7
%X Selection-based screening of large DNA-encoded libraries of drug-like small molecules is a validated method to identify bioactive compounds. Among the chemical space of bioactive compounds certain scaffold structures are well represented. These are commonly called “privileged scaffolds”. We have synthesized DNA-encoded libraries based on two representatives of these scaffolds, a benzodiazepine and a pyrazolopyrimidine, and additionally a third library based on propargyl glycine. All three core structures possess a carboxylic acid to couple them to aminolinker-modified DNA. For subsequent library synthesis they contained an amino function to which a set of carboxylic acid building blocks were coupled, and a terminal alkyne that was reacted with a set of azides to furnish triazoles. The two sets of building blocks, 114 carboxylic acids and 104 azides, were selected with the help of chemoinformatic methods in order to control the physicochemical properties of the final libraries, remove unwanted substructures, and maximize diversity. The set of building blocks contained desthiobiotin allowing for validation of library synthesis. The DNA-encoded libraries were synthesized by split-and-pool combinatorial chemistry yielding three libraries that contain 28.254 compounds together. For DNA barcoding, 5′-phosphorylated double-stranded coding DNA sequences with four base overhangs were ligated with T4 ligase. The resulting DNA-encoded libraries were compared to bioactivity databases and, though being based on core structures well-established in medicinal chemistry, showed novelty with respect to the known bioactive chemical space.

Chemical Biology Probes from Advanced DNA-encoded Libraries Salamon, Hazem; Škopi’c, Mateja Klika; Jung, Kathrin; Bugain, Olivia; Brunschweiger, Andreas in ACS Chemical Biology (2016). 11(2) 296–307.

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%0 Journal Article
%1 Salamon_2016
%A Salamon, Hazem
%A Škopi'c, Mateja Klika
%A Jung, Kathrin
%A Bugain, Olivia
%A Brunschweiger, Andreas
%D 2016
%I American Chemical Society (ACS)
%J ACS Chemical Biology
%N 2
%P 296--307
%R 10.1021/acschembio.5b00981
%T Chemical Biology Probes from Advanced DNA-encoded Libraries
%U https://doi.org/10.1021%2Facschembio.5b00981
%V 11

Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC Brunschweiger, A.; Gebert, L. F. R.; Lucic, M.; Pradère, U.; Jahns, H.; Berk, C.; Hunziker, J.; Hall, J. in Chem. Commun. (2016). 52(1) 156–159.

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%0 Journal Article
%1 C5CC07478A
%A Brunschweiger, A.
%A Gebert, L. F. R.
%A Lucic, M.
%A Pradère, U.
%A Jahns, H.
%A Berk, C.
%A Hunziker, J.
%A Hall, J.
%D 2016
%I The Royal Society of Chemistry
%J Chem. Commun.
%N 1
%P 156-159
%R 10.1039/C5CC07478A
%T Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC
%U http://dx.doi.org/10.1039/C5CC07478A
%V 52
%X We synthesized a miR-122 antimiR library in which drug-like fragments were site-specifically introduced to short 2′-O-methyl-RNAs. At some sites selected fragments elevated cellular antimiR activity to that of an unmodified 23mer antimiR, whereas at others the same fragments abolished activity. The potency of the antimiRs correlated with uptake into miRISC.

8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors Brunschweiger, Andreas; Koch, Pierre; Schlenk, Miriam; Rafehi, Muhammad; Radjainia, Hamid; Küppers, Petra; Hinz, Sonja; Pineda, Felipe; Wiese, Michael; Hockemeyer, Jörg; Heer, Jag; Denonne, Frédéric; Müller, Christa E. in Bioorganic \&amp$$\mathsemicolon$$ Medicinal Chemistry (2016). 24(21) 5462–5480.

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%0 Journal Article
%1 Brunschweiger_2016
%A Brunschweiger, Andreas
%A Koch, Pierre
%A Schlenk, Miriam
%A Rafehi, Muhammad
%A Radjainia, Hamid
%A Küppers, Petra
%A Hinz, Sonja
%A Pineda, Felipe
%A Wiese, Michael
%A Hockemeyer, Jörg
%A Heer, Jag
%A Denonne, Frédéric
%A Müller, Christa E.
%D 2016
%I Elsevier BV
%J Bioorganic \&\($\mathsemicolon$\) Medicinal Chemistry
%N 21
%P 5462--5480
%R 10.1016/j.bmc.2016.09.003
%T 8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors
%U https://doi.org/10.1016%2Fj.bmc.2016.09.003
%V 24

8-Benzyltetrahydropyrazino[2,1-f]purinediones: Water-Soluble Tricyclic Xanthine Derivatives as Multitarget Drugs for Neurodegenerative Diseases Brunschweiger, Andreas; Koch, Pierre; Schlenk, Miriam; Pineda, Felipe; Küppers, Petra; Hinz, Sonja; Köse, Meryem; Ullrich, Stefan; Hockemeyer, Jörg; Wiese, Michael; Heer, Jag; Müller, Christa E. in ChemMedChem (2014). n/a-n/a.

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%0 Journal Article
%1 Brunschweiger_2014
%A Brunschweiger, Andreas
%A Koch, Pierre
%A Schlenk, Miriam
%A Pineda, Felipe
%A Küppers, Petra
%A Hinz, Sonja
%A Köse, Meryem
%A Ullrich, Stefan
%A Hockemeyer, Jörg
%A Wiese, Michael
%A Heer, Jag
%A Müller, Christa E.
%D 2014
%I Wiley
%J ChemMedChem
%P n/a--n/a
%R 10.1002/cmdc.201402082
%T 8-Benzyltetrahydropyrazino[2,1-f]purinediones: Water-Soluble Tricyclic Xanthine Derivatives as Multitarget Drugs for Neurodegenerative Diseases
%U https://doi.org/10.1002%2Fcmdc.201402082

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases Koch, Pierre; Akkari, Rhalid; Brunschweiger, Andreas; Borrmann, Thomas; Schlenk, Miriam; Küppers, Petra; Köse, Meryem; Radjainia, Hamid; Hockemeyer, Jörg; Drabczyńska, Anna; Kie’c-Kononowicz, Katarzyna; Müller, Christa E. in Bioorganic \&amp$$\mathsemicolon$$ Medicinal Chemistry (2013). 21(23) 7435–7452.

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%0 Journal Article
%1 Koch_2013
%A Koch, Pierre
%A Akkari, Rhalid
%A Brunschweiger, Andreas
%A Borrmann, Thomas
%A Schlenk, Miriam
%A Küppers, Petra
%A Köse, Meryem
%A Radjainia, Hamid
%A Hockemeyer, Jörg
%A Drabczyńska, Anna
%A Kie'c-Kononowicz, Katarzyna
%A Müller, Christa E.
%D 2013
%I Elsevier BV
%J Bioorganic \&\($\mathsemicolon$\) Medicinal Chemistry
%N 23
%P 7435--7452
%R 10.1016/j.bmc.2013.09.044
%T 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases
%U https://doi.org/10.1016%2Fj.bmc.2013.09.044
%V 21

Virtual Screening Identifies Novel Sulfonamide Inhibitors of ecto-5’-Nucleotidase Ripphausen, Peter; Freundlieb, Marianne; Brunschweiger, Andreas; Zimmermann, Herbert; Müller, Christa E.; Bajorath, Jürgen in Journal of Medicinal Chemistry (2012). 55(14) 6576–6581.

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%0 Journal Article
%1 Ripphausen_2012
%A Ripphausen, Peter
%A Freundlieb, Marianne
%A Brunschweiger, Andreas
%A Zimmermann, Herbert
%A Müller, Christa E.
%A Bajorath, Jürgen
%D 2012
%I American Chemical Society (ACS)
%J Journal of Medicinal Chemistry
%N 14
%P 6576--6581
%R 10.1021/jm300658n
%T Virtual Screening Identifies Novel Sulfonamide Inhibitors of ecto-5'-Nucleotidase
%U https://doi.org/10.1021%2Fjm300658n
%V 55

P2 Receptors Activated by Uracil Nucleotides - An Update Brunschweiger, Andreas; Muller, Christa in Current Medicinal Chemistry (2006). 13(3) 289–312.

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%0 Journal Article
%1 Brunschweiger_2006
%A Brunschweiger, Andreas
%A Muller, Christa
%D 2006
%I Bentham Science Publishers Ltd.
%J Current Medicinal Chemistry
%N 3
%P 289--312
%R 10.2174/092986706775476052
%T P2 Receptors Activated by Uracil Nucleotides - An Update
%U https://doi.org/10.2174%2F092986706775476052
%V 13

Medizinische Chemie der Diuretika: Entwicklung einer erfolgreichen Wirkstoffgruppe Brunschweiger, Andreas; Müller, Christa in Pharmazie in unserer Zeit (2006). 35(4) 310–320.

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%0 Journal Article
%1 Brunschweiger_2006
%A Brunschweiger, Andreas
%A Müller, Christa
%D 2006
%I Wiley
%J Pharmazie in unserer Zeit
%N 4
%P 310--320
%R 10.1002/pauz.200600178
%T Medizinische Chemie der Diuretika: Entwicklung einer erfolgreichen Wirkstoffgruppe
%U https://doi.org/10.1002%2Fpauz.200600178
%V 35

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