Deutsch Intern
Institute for Pharmacy and Food Chemistry


Research Paper

Investigation of isomerization of dexibuprofen in a ball mill using chiral capillary electrophoresis.
Urlaub, J., Kaiser, R.P., Scherf‐Clavel, O., Bolm, C., Holzgrabe, U., Electrophoresis (2021), in press

Development and validation of a sensitive liquid chromatography tandem mass spectrometry assay for the simultaneous determination of ten kinase inhibitors in human serum and plasma.         
Aghai, F., Zimmermann, S., Kurlbaum, M., Jung, P., Pelzer, T., Klinker, H., Isberner, N., Scherf-Clavel, O., Anal Bioanal Chemistry, (2020)
doi: 10.1007/s00216-020-03031-7

Objective response and prolonged disease control of advanced adrenocortical carcinoma with cabozantinib 
Kroiss, M., Megerle, F., Kurlbaum, M., Zimmermann, S., Wendler, J., Jimenez, C., Lapa, c., Quinkler, M., Scherf-Clavel, O.,  Amir Habra, M., Fassnacht, M., J Clin Endo Metab, (2020), Volume 105, 1461-1468
doi: 10.1210/clinem/dgz318

Glycerolipid Composition and Advanced Physicochemical Considerations of Sacha Inchi Oil toward Cosmetic Products Formulation 
Penagos-Calvete D.,Duque, V, Marimon, C., Parra ,D. M.,  Restrepo-Arango, S. K., Scherf-Clavel, O., Holzgrabe, U., Montoya G.,  Salamanca C. H., Cosmetics, (2019), Volume 6
doi: 10.3390/cosmetics6040070

Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies
Scherf-Clavel, O., Kinzig, M., Stoffel, M.S., Fuhr, U., Sörgel, F., J Chrom B, (2019), Volume 1125, 121718
doi: 10.1016/j.jchromb.2019.121718

A HILIC-MS/MS assay for the quantification of metformin and sitagliptin in human plasma and urine: A tool for studying drug transporter perturbation
Scherf-Clavel, O., Kinzig, M., Stoffel, M.S., Fuhr, U., Sörgel, F., J Pharm Biomed Anal, (2019), Volume 175, 112754
doi: 10.1016/j.jpba.2019.07.002

A Clinical DDI Study Assessing a Novel Drug Transporter Phenotyping Cocktail with Adefovir, Sitagliptin, Metformin, Pitavastatin and Digoxin
Trueck, C., Hsin, C.H., Scherf-Clavel, O., Schaeffler, E., Lenssen, R., Gazzaz, M., Gersie, M., Taubert, M., Quasdorff, M., Schwab, M., Kinzig, M., Sörgel, F., Stoffel, M., Fuhr, U., Clinical Pharmacology and Therapeutics, (2019), Volume 106, Pages 1398-1407 
doi: 10.1002/cpt.1564

Determination of hydroxybupropion in human serum for routine therapeutic drug monitoring in psychiatry: a tool for dose-individualization in the treatment with bupropion
Scherf-Clavel, M., Wahl, O., Menke, A., Unterecker, S., Biomed Chrom, (2019), Volume 33, e4609
doi: 10.1002/bmc.4609

A method for the minimally invasive drug monitoring of mitotane by means of volumetric absorptive microsampling for a home-based therapeutic drug monitoring
Friedl, B., Kurlbaum, M., Kroiss, M., Fassnacht, M., Scherf-Clavel, O., Analytical and Bioanalytical Chemistry (2019), Volume 411, (2019) Pages 3951-3962
doi: 10.1007/s00216-019-01868-1

The contamination of valsartan and other sartans, part 1: New findings
Sörgel, F., Kinzig, M., Abdel-Tawab, M., Bidmon, C., Schreiber, A., Ermel, S., Wohlfart, J., Besa, A., Scherf-Clavel, O., Holzgrabe, U., J Pharm Biomed Anal (2019), Volume 172, (2019) Pages 278-284
doi: 10.1016/j.jpba.2019.05.022

The contamination of valsartan and other sartans, Part 2: Untargeted screening reveals contamination with amides additionally to known nitrosamine impurities
Scherf-Clavel, O., Kinzig, M., Besa, A., Schreiber, A.,Bidmon, C., Abdel-Tawab, M., Wohlfart, J., Sörgel, F., Holzgrabe, U., J Pharm Biomed Anal, Volume 172 (2019), Pages 278-284
doi: 10.1016/j.jpba.2019.04.035

Development and validation of a new UHPLC method for related proteins in insulin and insulin analogues as an alternative to the European Pharmacopoeia RP-HPLC method
Wahl, O., Jorajuria, S., J Pharm Biomed Anal (2018), Volume 166, (2019), Pages 71-82

Impurity profiling of N,N′-ethylenebis-l-cysteine diethyl ester (Bicisate)
Wahl, O., Cleynhens, J., Verbruggen, A., Holzgrabe, U. J Pharm Biomed Anal, Volume 150C (2018), Pages 132 – 136

Quantification of Hydrochlorothiazide and Ramipril/Ramiprilate in Blood Serum and Cerebrospinal Fluid: A Pharmacokinetic Assessment of Central Nervous System Adverse Effects
Sigaroudi, A., Kinzig, M., Wahl, O., Stelzer, C., Schroeter, M., Fuhr, U., Holzgrabe, U., Sörgel, F., Pharmacology, Volume 102 (2018), Pages 133 – 137

Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.
Sigaroudi, A., Kinzig, M., Wahl, O., Stelzer, C., Schroeter, M., Fuhr, U., Holzgrabe, U., Sörgel, F., Pharmacology, Volume 101 (2018), Pages 29 – 34

Impurity Profiling of Ibandronate sodium by HPLC-CAD. 
Wahl, O., Holzgrabe, U., J Pharm Biomed Anal, Volume 114 (2015), Pages 254 – 264doi:10.1016/j.jpba.2015.06.002

Evaluation of Enantiomeric Purity of Magnesium-L-aspartate Dihydrate. 
Wahl, O., Holzgrabe, U., J Pharm Biomed Anal, Volume 102 (2015), Pages 100 – 109doi:10.1016/j.jpba.2014.08.013

Impurity Profiling of Carbocisteine by HPLC-CAD, qNMR and UV/vis Spectroscopy. 
Wahl, O., Holzgrabe, U., J Pharm Biomed Anal, Volume 95 (2014), Pages 1 – 10 doi:10.1016/j.jpba.2014.02.012 



Therapeutic drug monitoring of oral targeted antineoplastic drugs.
Mueller-Schoell, A., Groenland, S., Scherf-Clavel, O., Van Dyk, M., Huisinga, W., Michelet, R., Jaehde, U., Steeghs, N., Huitema, A.D.R., Kloft, C., Eur J Clin Pharmacol (2020); doi: 10.1007/s00228-020-03014-8

Amino Acid Analysis for Pharmacopoeial Purposes. 
Wahl, O., Holzgrabe, U., Talanta, Volume 154 (2016), Pages 150 – 163; doi:10.1016/j.talanta.2016.03.071

Inhibition of Tumor Angiogenesis by Antibodies, Synthetic Small Molecules and Natural Products.
Wahl, O., Oswald, M., Tretzel, L., Herres, E., Arend, J., Efferth, T., Curr Med Chem, Volume 18 (2011), Pages 3136 – 3155; doi: 10.2174/092986711796391570



Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent hemodialysis 
Sörgel, F., Malin, J.J., Hagmann, H., Kinzig, M., Bilal, M., Eichenauer, D.A., Scherf-Clavel, O., Simonis, A., El Tabei, L., Fuhr, U., Rybniker, J., J Antimicrob Chemother, (2020)
doi: 10.1093/jac/dkaa500

CaboACC: Cabozantinib beim fortgeschrittenen Nebennierenkarzinom nach Versagen der Standardtherapie / CaboACC: Cabozantinib in advanced adrenocortical carcinoma after failure of standard therapy
Kroiß M., Goebeler, M.E., Röser, C., Zimmermann, S., Landwehr, L., Scherf-Clavel, O., Malzahn, U., Kurlbaum, M., Faßnacht, M., Forum, Sektion B – Klinische Studien, in press (2019)
doi: 10.1007/s12312-019-0632-3