Changing photo responsivity of light tunable drug substances10.11.2020
Congratulations to Johannes Wiest & team. They outlined an approach to make photo-unresponsive drug substances (unresponsive in terms of their physical-chemical properties) photo responsive by ion-pairing these to photo-switchable counterions. Apparent solubility, dissolution rates, and supramolecular structures of the drug substances became controlled by light!
Graphical abstract is reprinted with permission from:
„Wiest, J., Kehrein, J., Saedtler, M., Schilling, K., Cataldi, E., Sotriffer, C., Holzgrabe, U., Rasmussen, T., Böttcher, B., Cronin-Golomb, M., Lehmann, M., Jung, N., Windbergs, M., Meinel, L. (2020). Controlling Supramolecular Structures of Drugs by Light. ACS Mol. Pharmaceutics. 2020 Oct 29, doi: 10.1021/acs.molpharmaceut.0c00720 [Epub ahead of print, Article ASAP].”
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