Congratulations to Josef Kehrein, Elena Reus, and all collaborators from the BASE-Lipid consortium! They applied a self-regulating microfluidic device, previously established for PEGylated LNPs by our group, on alternative formulations containing poly(2-oxazoline)s. The device autonomously produced particles with high encapsulation efficiency, which were further characterized morphologically through cryogenic transmission electron microscopy and small-angle X-ray scattering. In mice, LNPs decorated with these PEG alternatives exhibited increased biodistribution to the bone marrow and liver, and less to the spleen and pancreas.
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