Natalia Yuan Chen

Publications

“MD-Based Assessment of Covalent Inhibitors in Noncovalent Association Complexes: Learning from Cathepsin K as a Test Case”
E. Endres, N. Yuan Chen and C. Sotriffer
J. Chem. Inf. Model. 63 (10) (2023) 3186-3197
DOI: 10.1021/acs.jcim.3c00061

"Glycolytic flux control by drugging phosphoglycolate phosphatase"
E. Jeanclos, J. Schlötzer, K. Hadamek, N. Yuan-Chen, M. Alwahsh, R. Hollmann, S. Fratz, D. Yesilyurt-Gerhards, T. Frankenbach, D. Engelmann, A. Keller, A. Kaestner, W. Schmitz, M. Neuenschwander, R. Hergenröder, C. Sotriffer, J. P. von Kries, H. Schindelin and A. Gohla
Nat. Commun. 13 (1) (2022) 6845
DOI: 10.1038/s41467-022-34228-2

"Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse Model"
F. He, C. J. Chou, M. Scheiner, E. Poeta, N. Yuan Chen, S. Gunesch, M. Hoffmann, C. Sotriffer, B. Monti, T. Maurice and M. Decker
J. Med. Chem. 64 (7) (2021) 3794–3812
DOI: 10.1021/acs.jmedchem.0c01940

"Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors"
M. Maspero, D. Volpato, D. Cirillo, N. Yuan Chen, R. Messerer, C. Sotriffer, M. De Amici, U. Holzgrabe, C. Dallanoce
Bioorg. Chem. 96 (2020) 103633
DOI: 10.1016/j.bioorg.2020.103633