Deutsch Intern
Institute for Pharmacy and Food Chemistry

Prof. Brunschweiger

Chairholder Pharmaceutical and Medicinal Chemistry

Tel.:  +49 (0) 931 / 31 - 82450
Room:  01.004

Institut für Pharmazie und Lebensmittelchemie
Am Hubland
D - 97074 Würzburg

Jan. 2023

University of Würzburg: Head of Chair Pharmaceutical and Medicinal Chemistry

Independent research

Feb. 2013 - Dec. 2022

Independent research group leader, TU Dortmund (DEL technology, micellar reactions, data science, TEAD-YAP inhibitors)

Postdoctoral research

Feb. 2010 – Jan. 2013

Post-doc with Prof. Jonathan Hall, ETH Zürich (microRNA target identification, microRNA inhibitors)

Aug. 2007 – Jan. 2010

Post-doc with Prof. Christa Müller, University of Bonn, with UCB Pharma (hit-to-lead for multitarget drugs)

Education and Qualification

Jan. 2020

Venia legendi, Habilitation for the subject “Medicinal Chemistry” (Faculty of Chemistry and Chemical Biology, TU Dortmund)

Sep. 2016

Qualification to head a biosafety level 1 laboratory

Aug. 2009     

„Fachapotheker für Arzneimittelinformation“

Oct. 2003 – Jul. 2007     

PhD thesis in the group of Prof. C. E. Müller, University of Bonn

Jul. 2002 – Jun. 2003     

“3. Abschnitt der Pharmazeutischen Ausbildung”

Mar. 1998 – Jun. 2002     

Study of Pharmacy, Pharmaceutical Institute, University of Kiel

Jul. 1999 – Aug. 1999

Internship with Prof. I. Ivanov, Pharmaceutical Institute, University of Sofia

  • Award "Forum Junge Spitzenforscher, zur Förderung des Transfers innovativer Ideen zum Thema Transformation", Dortmund, 2020, donated by the Foundation Industrieforschung
  • Innovationspreis in Medizinisch/Pharmazeutischer Chemie, 2019, awarded by the "Fachgruppe Medizinische Chemie der GDCh" and the "Fachgruppe Pharmazeutische/ Medizinische Chemie der DPhG", Würzburg, 2019
  • BioMedizin-Förderpreis des Vereins zur Förderung der biomedizinischen und klinischen Forschung e.V., Dortmund, 2017
  • Member of the “Global Young Faculty”, Mercator Research Center Ruhr (MERCUR), 2015.
  • Neuroallianz Publication Award (silver) 2014 for ChemMedChem 2014, 9, 1704–1724
  • Poster award for “Uracil nucleotide mimetics as NTPDase2 inhibitors”, 8th International Symposium on ‘Adenosine and Adenine Nucleotides’; Ferrara, 2006

  • PhD prize for Dr. Verena Kunig, FiMC (online), 2022
  • Poster prize for Dr. Suzanne Willems, FiMC (online), 2022
  • Poster prizes for Dr. Marco Potowski and Verena Kunig, FiMC (online), 2021
  • Poster prize for Verena Kunig, EFMC conference (online), 2020
  • Poster prize for Verena Kunig, 7th Int. conference on MCR Chemistry, Düsseldorf, 2019
  • Klaus-Grohe award for Dr. Mateja Klika Škopić, FiMC Jena, 2018
  • Nüsslein-Volhard scholarship for Mateja Klika Škopić to support mothers who pursue a scientific career, 2016

  • Frontiers in Medicinal Chemistry, March 2021 (online seminar)
  • Advances in Chemical Biology, January 2021 (online seminar)
  • Biochemistry, Münster, March 2020 (postponed due to coronavirus pandemia)
  • Chemiedozententagung, Dresden, March/April 2020 (cancelled due to coronavirus pandemia)
  • Bioheterocycles, Ghent, Belgium, June 2019
  • Leibniz Conference on Bioactive Compounds, Dresden, Germany, April 2019
  • Chemiedozententagung, Koblenz, April 2019
  • Advances in Chemical Biology, Frankfurt, Germany, January 2019
  • Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Hamburg, Germany, September 2018
  • 7th EuCheMS Chemistry Congress, Liverpool, UK, August, 2018
  • International Helmholtz Drug Discovery Conference, Munich, Germany, April 2018
  • Leibniz Conference on Bioactive Compounds, Halle, Germany, April 2018
  • Advances in Chemical Biology, Frankfurt, Germany, January 2018
  • Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Saarbrücken, Germany, September 2017
  • Molecular Basis of Life, conference organized by the German Society for Biochemistry and Molecular Biology, Bochum, Germany, September 2017
  • VIII. Nucleinsäurechemie-Treffen, Mainz, Germany, September 2017
  • 26th International Society of Heterocyclic Chemistry Congress, Regensburg, Germany, September 2017
  • 7th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), Vienna, Austria, August 2017
  • The Fourth International Scientific Conference “Advances in Synthesis and Complexing”, Moscow, Russia, April 2017
  • First German-Russian Interdisciplinary Student Workshop "Nanoscale Interdisciplinary Research: Physics, Chemistry, Biology, Mathematics", Moscow, Russia, April, 2017
  • Leibniz Conference on Bioactive Compounds, Freising, Germany, March 2017
  • Chemiedozententagung, Marburg, March 2017
  • International Conference “Modern Trends in Organic Chemistry”, Dombay, Russia, June 2016
  • Gemeinsames Symposium der Max-Planck-Gesellschaft und RIKEN, Berlin, Germany, April 2016

  • XXVII EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC) 2022, session head and invited talk
  • Elsevier/Reaxys, October 2021 (online seminar on KNIME for chemistry data analysis)
  • Drug Discovery UK, October 2021 (online seminar)
  • ACS National Meeting, March 2021 (online seminar)
  • Reaxys/Elsevier, February 2021 (online presentation in a user community meeting on our use of KNIME for chemistry database search)
  • eMolecules, November 2020 (online seminar)
  • Global Medicinal Chemistry Summit, November 2020 (online seminar)
  • Elsevier/Reaxys, October 2020 (online seminar)
  • AstraZeneca, September 2020 (online seminar)
  • Sanofi, May 2020 (online)
  • ACS National Meeting, San Francisco, USA, August 2020 (online due to coronavirus pandemia)
  • Pacifichem, Honolulu, USA, December 2020 (postponed to 2021, online)
  • ACS National Meeting, Philadelphia, USA, March 2020 (postponed due to coronavirus pandemia)
  • Global Medicinal Chemistry & Protein Degradation Summit, London, UK, October 2019
  • EFMC-YMCS congress, Athens, Greece, September 2019
  • Frontiers in Medicinal Chemistry, Berne, Switzerland, February 2017
  • Frontiers in Medicinal Chemistry, Würzburg, Germany, March 2019
  • Jungchemikerforum, Bochum, June 2018
  • Global Medicinal Chemistry & GPCR Leaders Summit, London, UK, November 2017
  • GTCBio European Pharma Summit, Berlin, Germany, November 2017
  • 7th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), Vienna, Austria, August 2017
  • ACS National Meeting, Washington DC, USA, August 2017
  • Cancer Research UK, London, UK, November 2017
  • Bayer AG, Wuppertal, Germany, March 2017
  • Novartis Pharma AG, Basel, Switzerland, March 2016

  • Prof. Alexander Dömling (U. Groningen): encoded Ugi reaction* and MDM2 inhibitor design*
  • Prof. Mike Waring (U. Newcastle): DNA-encoded Suzuki reactions,* academic DEL resource
  • Dr. Sam Butterworth (U. Manchester):  academic DEL resource
  • Prof. Ralf Weberskirch (TU Dortmund): nanoheterogeneous reaction systems for DEL synthesis*
  • Prof. Roland Fried (TU Dortmund): computer-assisted workflows for sequencing data analysis*
  • Prof. Norbert Kockmann (TU Dortmund): laboratory automation for DEL synthesis,* microreactors  
  • Prof. Stefan Kast (TU Dortmund): ligand/structure-based design of TEAD-YAP inhibitors
  • Dr. Christiane Ehrt (U. Hamburg): computational DEL design and chemical space analysis*
  • Dr. Alexander Vakalopoulus (Bayer): DNA-encoded library design*
  • Prof. Donat Kögel (U. Frankfurt): DEL design for Bcl proteins and BAG3
  • Prof. Jeffrey Bode (ETH Zürich): DEL chemistry development*

collaborations marked with an asterix have led to publications

Reviewer for journals

  • Angew. Chem. Int. Ed., J. Am. Chem. Soc., Nat. Chem., Nat. Commun., Org. Lett., ACS Chem. Biol., J. Med. Chem., MedChemComm., Bioconjug. Chem., Curr. Top. Med. Chem., Bioorg. Med. Chem.; ACS Comb. Sci.

Reviewer for third-party funding applications

  • Swiss National Fund (repeatedly)
  • National Research Council Canada

Editorial Activities

  • Guest editor for a Special Issue in Bioorganic and Medicinal Chemistry Letters on “DNA-encoded libraries” published in 2021 (15 contributions from the field).
  • Co-editor with Prof. Damian Young (Baylor College of Medicine, Houston, USA) of a book titled “DNA-encoded Chemistry” to be published within the series Topics in Medicinal Chemistry.

Member of scientific committee

  • Member of the International Scientific Committee of the XXVII International Symposium on Medicinal Chemistry 2022.


  • Gesellschaft Deutscher Chemiker (GDCh)
  • Deutsche Nucleinsäurechemiegemeinschaft (DNG)
  • Schweizerische Chemische Gesellschaft (SCG)
  • Deutsche Pharmazeutische Gesellschaft (DPhG)

Institutional activities

  • Participation in faculty teaching
  • Faculty member of the International Max Planck Research School “Chemical Biology” (since 2013)
  • Coordination of the lecture “Medicinal Chemistry II - Case Studies” which is in part given by scientists from the Lead Discovery Center GmbH, Dortmund, and Bayer Pharma AG, Wuppertal (since 2013)
  • Organization of excursions for MSc students of Chemical Biology to Bayer Pharma AG, Wuppertal (2014, 2015)
  • Member of three commissions to hire faculty (“Berufungskommissionen”)
  • Organization of the newly established institute´s colloquium: “Modern Drug Discovery” which has attracted regular attendance beyond the University (since 2013)
  • Lectures on drug research for school students, “Schnupper-Uni”, 2013-2015
  • Lectures on Medicinal Chemistry and Chemical Biology for chemistry teachers, Chemielehrerfortbildungen, 2014-2016

  • UK academic DNA-encoded library screening resource
    funded by the Wellcome Trust, with Prof. Mike Waring (University of Newcastle) and Dr. Sam Butterworth (University Manchester), co-applicant, May 2021 - April 2026.
  • Design and Screening of Advanced DNA-Encoded Libraries
    research project with Bayer AG, follow-up to successful delivery of project 6 “Expanding the chemical space of DNA-encoded libraries”, Dec. 2020 - Nov. 2022.
  • Entwicklung von Strategien zur Hochdurchsatzsynthese von genetisch kodierten Molekülbibliotheken heterocyclischer Systeme und Anwendung zur Identifizierung von Inhibitoren von Apoptose-Inhibitoren (IAP) als Modellsysteme
    funded by the DFG, Jul. 2020 - Jun. 2023, with Prof. Norbert Kockmann (Faculty of Chemical and Biological Engineering, TU Dortmund).
  • Validierung von polymergestützen, mizellaren Reaktoren für die Herstellung von genetisch kodierten Screeningbibliotheken
    EFRE-funded NRW-Patentvalidierung, main applicant: Prof. Weberskirch (TU Dortmund)Jan. 2020 - Dec. 2021.
  • Expanding the chemical space of DNA-encoded libraries
    research project with Bayer AG; July 2018 – July 2020.
  • Targeting the therapy resistance factors BAG3 und Bcl-xL in solid tumors
    funded by the DFG, collaboration project with Prof. Donat Kögel (University of Frankfurt), and Prof. Stefan Kast (TU Dortmund University); July 2018 – June 2021.
  • Funktion des APBB1 in Abhängigkeit seiner subzellulären Lokalisation - Relevanz für Morbus Alzheimer
    funded by Mercator Research Center Ruhr (MERCUR), co-applicant, with Dr. Thorsten Müller, University of Bochum, and Prof. Shirley Knauer, University of Duisburg-Essen; June 2017 May 2019.
  • Click & Code
    research project with Merck KGaA; November 2018 – April 2019.
  • Towards chemoresistant genetic information
    funded by Boehringer Ingelheim foundation; December 2017 – November 2018.