Startseite - Institut für Pharmazie und Lebensmittelchemie

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Pharmazeutische und Medizinische Chemie
Pharmazeutische Technologie und Biopharmazie
Lebensmittelchemie

Studium

Pharmazie (Staatsexamen)
Lebensmittelchemie (Bachelor/Master)

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Apr 18

DPhG-Vortrag am Dienstag, 18. April 2023
08040000-Pharmazie
Di, 18.04.2023, 20:15 Uhr

Mai 02

DPhG-Vortrag am Dienstag, 2. Mai 2023
08040000-Pharmazie
Di, 02.05.2023, 20:15 Uhr

Mai 23

DPhG-Vortrag am Dienstag, 23. Mai 2023
08040000-Pharmazie
Di, 23.05.2023, 20:15 Uhr

Jun 13

DPhG-Vortrag am Dienstag, 13. Juni 2023
08040000-Pharmazie
Di, 13.06.2023, 20:15 Uhr

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Simultaneous Determination of the Saponification Value, Acid Value, Ester Value, and Iodine Value in Commercially Available Red Fruit Oil (Pandanus conoideus, Lam.) Using 1H qNMR Spectroscopy Triyasmono, Liling; Schollmayer, Curd; Schmitz, Jens; Hovah, Emilie; Lombo, Cristian; Schmidt, Sebastian; Holzgrabe, Ulrike in Food Analytical Methods (2023). 16(1) 155–167.
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%0 Journal Article %1 Triyasmono2023 %A Triyasmono, Liling %A Schollmayer, Curd %A Schmitz, Jens %A Hovah, Emilie %A Lombo, Cristian %A Schmidt, Sebastian %A Holzgrabe, Ulrike %D 2023 %J Food Analytical Methods %N 1 %P 155--167 %R 10.1007/s12161-022-02401-4 %T Simultaneous Determination of the Saponification Value, Acid Value, Ester Value, and Iodine Value in Commercially Available Red Fruit Oil (Pandanus conoideus, Lam.) Using 1H qNMR Spectroscopy %U https://doi.org/10.1007/s12161-022-02401-4 %V 16 %X Red fruit oil (RFO) can be extracted from fruits of Pandanus conoideus, Lam., an endogenous plant of Papua, Indonesia. It is a commonly used essential original traditional medicine. By applying a newly developed quantitative 1H NMR (qNMR) spectroscopy method for quality assessment, a simultaneous determination of the saponification value (SV), acid value (AV), ester value (EV), and iodine value (IV) in RFO was possible. Dimethyl sulfone (DMSO2) was used as an internal standard. Optimization of NMR parameters, such as NMR pulse sequence, relaxation delay time, and receiver gain, finally established the 1H NMR-based quantification approach. Diagnostic signals of the internal standard at $$\delta$$thinspace=thinspace2.98 ppm, SV at $$\delta$$thinspace=thinspace2.37--2.20 ppm, AV at $$\delta$$thinspace=thinspace2.27--2.20 ppm, EV at $$\delta$$thinspace=thinspace2.37--2.27 ppm, and IV at $$\delta$$thinspace=thinspace5.37--5.27 ppm, respectively, were used for quantitative analysis. The method was validated concerning linearity (R2\thinspace=\thinspace0.999), precision (less than 0.83\%), and repeatability in the range 99.17--101.17%. Furthermore, this method was successfully applied to crude RFO, crude RFO with palmitic and oleic acid addition, and nine commercial products. The qNMR results for the respective fat values are in accordance with the results of standard methods, as can be seen from the F- and t-test (<\thinspace1.65 and\thinspace<\thinspace1.66, respectively). The fundamental advantages of qNMR, such as its rapidity and simplicity, make it a feasible and existing alternative to titration for the quality control of RFO.
Bridging the Binding Sites: Dualsteric Ligands for the Cannabinoid 2 Receptor (CB2R) Tutov, Anna; Steinmüller, Sophie A. M.; Ram’irez, Yesid A.; Jack, Christine E.; Rodr’iguez-Soacha, Diego A.; Sotriffer, Christoph; Hislop, James N.; Decker, Michael in Advanced Therapeutics (2023). 2200260.
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%0 Journal Article %1 Tutov_2023 %A Tutov, Anna %A Steinmüller, Sophie A. M. %A Ram'irez, Yesid A. %A Jack, Christine E. %A Rodr'iguez-Soacha, Diego A. %A Sotriffer, Christoph %A Hislop, James N. %A Decker, Michael %D 2023 %I Wiley %J Advanced Therapeutics %P 2200260 %R 10.1002/adtp.202200260 %T Bridging the Binding Sites: Dualsteric Ligands for the Cannabinoid 2 Receptor (CB2R) %U https://doi.org/10.1002%2Fadtp.202200260
Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions Potowski, Marco; Losch, Florian; Wünnemann, Elena; Dahmen, Janina K.; Chines, Silvia; Brunschweiger, Andreas in Chem. Sci. (2019). 10(45) 10481–10492.
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%0 Journal Article %1 C9SC04708E %A Potowski, Marco %A Losch, Florian %A Wünnemann, Elena %A Dahmen, Janina K. %A Chines, Silvia %A Brunschweiger, Andreas %D 2019 %I The Royal Society of Chemistry %J Chem. Sci. %N 45 %P 10481-10492 %R 10.1039/C9SC04708E %T Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions %U http://dx.doi.org/10.1039/C9SC04708E %V 10 %X DNA-encoded compound libraries are a widely used technology for target-based small molecule screening. Generally, these libraries are synthesized by solution phase combinatorial chemistry requiring aqueous solvent mixtures and reactions that are orthogonal to DNA reactivity. Initiating library synthesis with readily available controlled pore glass-coupled DNA barcodes benefits from enhanced DNA stability due to nucleobase protection and choice of dry organic solvents for encoded compound synthesis. We screened the compatibility of solid-phase coupled DNA sequences with 53 metal salts and organic reagents. This screening experiment suggests design of encoded library synthesis. Here, we show the reaction optimization and scope of three sp3-bond containing heterocyclic scaffolds synthesized on controlled pore glass-connected DNA sequences. A ZnCl2-promoted aza-Diels–Alder reaction with Danishefsky's diene furnished diverse substituted DNA-tagged pyridones, and a phosphoric acid organocatalyst allowed for synthesis of tetrahydroquinolines by the Povarov reaction and pyrimidinones by the Biginelli reaction, respectively. These three reactions caused low levels of DNA depurination and cover broad and only partially overlapping chemical space though using one set of DNA-coupled starting materials.

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DPhG-Vortrag am Dienstag, 18. April 2023

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Schnelleinstieg

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